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Describe the Glycoxylate cycle.

Describe the Glycoxylate cycle.

Answer in cell biology
Course: B.Sc
1 Answer

Glycoxylate cycle is a specific pathway for formation of carbohydrates (glucose) from Acetyl CoA. This cycle is present only in plants and micro-organism. Glyoxylate cycle take place in glyoxysomes of all bearing cells. Glyoxysomes contain iso enzymes of three enzymes of the TCA cycle, citrate synthase, aconotase hydratase and malate dehydrogenase. Two additional enzymes isocitrate lysase and malate synthetase are special enzymes for the cycle. Isocitrate lyase leaves 6 — carbon isocitrate to 4 carbon succinate and 2 carbon glycoxylate.

Succinate leave glyoxysomes and enter into mitochondria. In mitochondria succinate is converted into malate via fumarate using part of the TCA cycle. Malate now moves into a cytoplasm where it is converted into phosphoenol pyruvate (PEP) via OAA. PPP forms glucose via gluconeogenesis. See the whole process of glycoxylate cycle by this diagram:

Glyoxyate CycleGlyoxyate Cycle

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